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Area / 06

CIP / SIP Systems

  • ISA-88
  • CIP/SIP
  • Cycle recipe
  • GAMP 5
  • DeltaV
  • Siemens PCS 7
  • DCS-MES integration

Poorly designed CIP/SIP automation is one of the most consistent sources of GMP deviation we see — and one of the most preventable. The control logic determines whether a cleaning or sterilisation cycle achieves its validated endpoints every time, or whether an operator is compensating for a sequence that does not quite work. Our Process Automation Engineers build CIP/SIP automation so the cycle runs, the endpoints are hit, the record is complete and there is no ambiguity about whether equipment was clean and sterile before the batch started.

We treat CIP and SIP as primary batch automation disciplines — ISA-88 phase logic within the DCS, validated recipes managed through MES, automated deviation detection and a DCS-MES interface that produces a complete, automatically generated cycle record. Not utility programmes written during commissioning and never properly reviewed.

CIP / SIP Systems

Where we deliver

  1. 01

    CIP Sequence Design and DCS Configuration

    Pre-rinse, caustic wash, intermediate rinse, acid wash and final rinse — designed as discrete ISA-88 phases within the DCS with defined entry conditions, hold logic, alarm limits and exit criteria. Temperature, flow, pressure and conductivity controlled and verified at every step. Interlocks ensure each phase only starts when the previous phase is properly complete and documented. No shortcuts, no operator workarounds.

  2. 02

    SIP Sequence and Phase Logic

    SIP sequences built as ISA-88 recipes — temperature set points, hold times, steam penetration verification and automatic pass/fail determination. We configure SIP logic so the cycle either achieves the validated endpoint or generates a documented failure. Never a successful cycle with unrecorded anomalies. The sequence is built to support qualification from the outset.

  3. 03

    MES Recipe Management and Electronic Cycle Records

    CIP and SIP cycles managed as MES recipes — automated pass/fail determination against validated acceptance criteria, deviation management and direct integration into the broader batch record. No paper-based cycle logs. No manual transcription of temperature profiles. No gap between what the DCS executed and what the record shows.

  4. 04

    ILD for Caustic and Chemical Dosing

    Where CIP systems use ILD to dilute concentrated caustic or acid solutions inline — DCS controls the dilution ratio through real-time conductivity feedback, ensuring the correct concentration reaches the equipment being cleaned at the correct flow rate. The same precise control logic applies as in buffer preparation ILD — the chemistry differs, the engineering requirement is identical.

Next

CIP/SIP appears in every process area — bioreactors, chromatography skids, buffer tanks, filling line components. When we deliver DCS and MES work in mammalian, microbial or fill-finish areas, CIP/SIP sequences are part of that scope. In tech transfer programmes, we map CIP recipe structures and SIP cycle parameters as part of the control philosophy alignment. CQV support available where required.

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